Sensitivity analysis 3: the association of pneumonia between birth to age 20 years and multiple sclerosis with onset and diagnosis over 20 years of age
| Primary or secondary diagnosis of pneumonia | |||||
| Age group | Cases n (%) | Cont n (%) | Model 1 OR (95% CI)* | Model 2 OR (95% CI)* | Model 3 OR (95% CI)* |
| 4244 | 34 250 | ||||
| Pneumonia | |||||
| 0–5 | 36 (0.85) | 337 (0.98) | 0.86 (0.61 to 1.22) | 0.86 (0.60 to 1.21) | 0.86 (0.60 to 1.21) |
| 6–10 | 9 (1.07) | 108 (0.32) | 0.66 (0.34 to 1.31) | 0.67 (0.34 to 1.33) | 0.67 (0.34 to 1.34) |
| 11–15 | 13 (2.07) | 61 (0.18) | 1.72 (0.95 to 3.14) | 1.71 (0.94 to 3.13) | 1.71 (0.94 to 3.12) |
| 16–20 | 13 (3.07) | 75 (0.22) | 1.43 (0.79 to 2.57) | 1.39 (0.77 to 2.51) | 1.38 (0.76 to 2.5) |
| IM | |||||
| 0–5 | 3 (0.07) | 17 (0.05) | 1.34 (0.39 to 4.60) | 1.34 (0.39 to 4.59) | |
| 6–10 | 6 (0.14) | 25 (0.07) | 1.85 (0.75 to 4.53) | 1.86 (0.76 to 4.55) | |
| 11–15 | 31 (0.73) | 72 (0.21) | 3.44 (2.25 to 5.25) | 3.44 (2.25 to 5.25) | |
| 16–20 | 40 (0.94) | 122 (0.36) | 2.58 (1.80 to 3.71) | 2.59 (1.80 to 3.72) | |
| Primary diagnosis of pneumonia | |||||
| 4244 | 34 250 | ||||
| Pneumonia | |||||
| 0–5 | 31 (0.73) | 253 (0.74) | 0.99 (0.68 to 1.44) | 0.98 (0.67 to 1.42) | 0.98 (0.67 to 1.42) |
| 6–10 | 9 (0.21) | 82 (0.24) | 0.87 (0.43 to 1.73) | 0.87 (0.43 to 1.74) | 0.88 (0.44 to 1.75) |
| 11–15 | 11 (0.26) | 49 (0.14) | 1.77 (0.92 to 3.41) | 1.79 (0.93 to 3.44) | 1.78 (0.92 to 3.43) |
| 16–20 | 10 (0.24) | 69 (0.2) | 1.20 (0.62 to 2.33) | 1.16 (0.60 to 2.26) | 1.16 (0.59 to 2.25) |
| IM | |||||
| 0–5 | 3 (0.07) | 17 (0.05) | 1.33 (0.39 to 4.58) | 1.33 (0.39 to 4.57) | |
| 6–10 | 6 (0.14) | 25 (0.07) | 1.86 (0.76 to 4.57) | 1.87 (0.76 to 4.59) | |
| 11–15 | 31 (0.73) | 72 (0.21) | 3.44 (2.25 to 5.26) | 3.44 (2.25 to 5.25) | |
| 16–20 | 40 (0.94) | 122 (0.36) | 2.59 (1.81 to 3.72) | 2.60 (1.81 to 3.73) | |
Bold text indicates results where the 95% CI does not cross 1.00.
*Model 1: adjusted for matching variables; model 2: adjusted for matching variables and IM; model 3: adjusted for matching variables, IM and education. In all models, the OR is comparing having a diagnosis within the age group with not having a diagnosis in the age group.
Cont, controls; IM, infectious mononucleosis; n, total individuals in group.