Age group | Cases n (%) | Cont n (%) | Model 1 OR (95% CI)* | Model 2 OR (95% CI)* | Model 3 OR (95% CI)* | Model 4 OR (95% CI)* |
Case definition 1† | 6109 | 49 479 | ||||
Pneumonia | ||||||
0–5 | 51 (0.83) | 498 (1.01) | 0.82 (0.62 to 1.10) | 0.82 (0.61 to 1.10) | 0.82 (0.61 to 1.10) | 0.81 (0.61 to 1.09) |
6–10 | 16 (0.26) | 161 (0.33) | 0.80 (0.48 to 1.34) | 0.79 (0.47 to 1.33) | 0.79 (0.47 to 1.33) | 0.79 (0.47 to 1.33) |
11–15 | 20 (0.33) | 81 (0.16) | 2.00 (1.22 to 3.27) | 2.00 (1.22 to 3.27) | 2.02 (1.23 to 3.30) | 2.00 (1.22 to 3.27) |
16–20 | 19 (0.31) | 112 (0.23) | 1.38 (0.84 to 2.24) | 1.34 (0.82 to 2.18) | 1.33 (0.82 to 2.17) | 1.31 (0.80 to 2.13) |
IM | ||||||
0–5 | 6 (0.1) | 21 (0.04) | 2.14 (0.86 to 5.33) | 2.13 (0.86 to 5.31) | 2.14 (0.86 to 5.34) | |
6–10 | 9 (0.15) | 37 (0.07) | 1.90 (0.91 to 3.94) | 1.89 (0.91 to 3.94) | 1.93 (0.93 to 4.00) | |
11–15 | 36 (0.59) | 106 (0.21) | 2.76 (1.89 to 4.04) | 2.77 (1.89 to 4.05) | 2.77 (1.89 to 4.06) | |
16–20 | 51 (0.83) | 178 (0.36) | 2.28 (1.66 to 3.12) | 2.27 (1.66 to 3.11) | 2.29 (1.68 to 3.14) | |
UTI | ||||||
0–5 | 39 (0.64) | 317 (0.64) | 0.97 (0.69 to 1.36) | 0.96 (0.69 to 1.35) | ||
6–10 | 27 (0.44) | 195 (0.39) | 1.11 (0.74 to 1.67) | 1.10 (0.74 to 1.66) | ||
11–15 | 10 (0.16) | 104 (0.21) | 0.69 (0.36 to 1.33) | 0.68 (0.35 to 1.31) | ||
16–20 | 60 (0.98) | 362 (0.73) | 1.32 (1.00 to 1.74) | 1.30 (0.98 to 1.71) | ||
Case definition 2‡ | 5592 | 43 327 | ||||
Pneumonia | ||||||
0–5 | 46 (0.82) | 428 (0.99) | 0.84 (0.61 to 1.15) | 0.83 (0.61 to 1.14) | 0.83 (0.61 to 1.14) | 0.83 (0.6 to 1.13) |
6–10 | 15 (0.27) | 147 (0.34) | 0.77 (0.44 to 1.33) | 0.77 (0.44 to 1.34) | 0.77 (0.44 to 1.34) | 0.77 (0.44 to 1.34) |
11–15 | 17 (0.3) | 74 (0.17) | 1.88 (1.11 to 3.19) | 1.87 (1.10 to 3.18) | 1.91 (1.13 to 3.25) | 1.90 (1.12 to 3.23) |
16–20 | 17 (0.3) | 94 (0.22) | 1.32 (0.77 to 2.29) | 1.28 (0.74 to 2.22) | 1.28 (0.74 to 2.22) | 1.27 (0.73 to 2.19) |
IM | ||||||
0–5 | 5 (0.09) | 20 (0.05) | 1.57 (0.54 to 4.60) | 1.56 (0.53 to 4.57) | 1.58 (0.54 to 4.63) | |
6–10 | 9 (0.16) | 27 (0.06) | 2.35 (1.06 to 5.18) | 2.34 (1.06 to 5.16) | 2.37 (1.07 to 5.24) | |
11–15 | 36 (0.64) | 93 (0.21) | 2.98 (2.01 to 4.44) | 3.01 (2.03 to 4.48) | 3.01 (2.03 to 4.48) | |
16–20 | 47 (0.84) | 150 (0.35) | 2.33 (1.66 to 3.27) | 2.32 (1.65 to 3.25) | 2.33 (1.66 to 3.28) | |
UTI | ||||||
0–5 | 33 (0.64) | 275 (0.63) | 0.90 (0.62 to 1.31) | 0.89 (0.61 to 1.30) | ||
6–10 | 24 (0.43) | 169 (0.39) | 1.16 (0.75 to 1.79) | 1.16 (0.75 to 1.79) | ||
11–15 | 7 (0.13) | 94 (0.22) | 0.53 (0.25 to 1.16) | 0.53 (0.24 to 1.14) | ||
16–20 | 54 (0.97) | 317 (0.73) | 1.32 (0.98 to 1.78) | 1.30 (0.96 to 1.75) |
Bold text indicates results where the 95% CI does not cross 1.00.
*Model 1: adjusted for matching variables; model 2: adjusted for matching variables and IM; model 3: adjusted for matching variables, IM and UTIs; model 4: adjusted for matching variables, IM and education. In all models, the OR is comparing having a diagnosis within the age group with not having a diagnosis in the age group.
†Case definition 1: at least one MS diagnosis over age 20 years from the PR or MSR.
‡Case definition 2: two or more MS diagnoses over age 20 years from the PR or diagnosis in the MSR.
Cont, controls; IM, infectious mononucleosis; MSR, Multiple Sclerosis Register; n, total individuals in group; PR, National Patient Register; UTI, urinary tract infection.