Sensitivity analysis 2: the association of a primary or secondary diagnosis of pneumonia between birth and age 30 years and multiple sclerosis diagnosed over 30 years of age
| Age group | Cases n (%) | Cont n (%) | Model 1 OR (95% CI)* | Model 2 OR (95% CI)* | Model 3 OR (95% CI)* |
| Case definition 1† | 3457 | 27 462 | |||
| Pneumonia | |||||
| 0–5 | 21 (0.61) | 157 (0.57) | 1.03 (0.65 to 1.62) | 1.03 (0.65 to 1.63) | 1.01 (0.64 to 1.60) |
| 6–10 | 10 (0.29) | 82 (0.3) | 0.92 (0.47 to 1.77) | 0.92 (0.47 to 1.78) | 0.92 (0.48 to 1.79) |
| 11–15 | 11 (0.32) | 48 (0.17) | 1.77 (0.92 to 3.42) | 1.79 (0.92 to 3.45) | 1.75 (0.90 to 3.38) |
| 16–20 | 11 (0.32) | 58 (0.21) | 1.50 (0.78 to 2.87) | 1.44 (0.75 to 2.77) | 1.43 (0.74 to 2.74) |
| 21–30 | 20 (0.58) | 162 (0.59) | 0.98 (0.62 to 1.56) | 0.99 (0.62 to 1.57) | 0.95 (0.60 to 1.52) |
| IM | |||||
| 0–5 | 1 (0.03) | 11 (0.04) | 0.65 (0.08 to 5.04) | 0.65 (0.08 to 5.05) | |
| 6–10 | 5 (0.14) | 15 (0.05) | 2.31 (0.83 to 6.42) | 2.36 (0.85 to 6.57) | |
| 11–15 | 20 (0.58) | 64 (0.23) | 2.50 (1.51 to 4.14) | 2.50 (1.51 to 4.15) | |
| 16–20 | 32 (0.93) | 74 (0.27) | 3.29 (2.17 to 4.99) | 3.34 (2.20 to 5.08) | |
| 21–30 | 13 (0.38) | 40 (0.15) | 2.60 (1.39 to 4.88) | 2.61 (1.39 to 4.89) | |
| Case definition 2‡ | 3145 | 23 736 | |||
| Pneumonia | |||||
| 0–5 | 20 (0.64) | 127 (0.05) | 1.17 (0.72 to 1.90) | 1.17 (0.72 to 1.91) | 1.16 (0.71 to 1.89) |
| 6–10 | 9 (0.29) | 73 (0.03) | 0.90 (0.45 to 1.82) | 0.92 (0.46 to 1.85) | 0.93 (0.46 to 1.86) |
| 11–15 | 9 (0.29) | 45 (0.02) | 1.56 (0.76 to 3.21) | 1.58 (0.77 to 3.23) | 1.54 (0.75 to 3.17) |
| 16–20 | 11 (0.35) | 48 (0.02) | 1.53 (0.74 to 3.12) | 1.44 (0.70 to 2.97) | 1.42 (0.69 to 2.93) |
| 21–30 | 18 (0.57) | 139 (0.06) | 1.04 (0.64 to 1.71) | 1.05 (0.64 to 1.72) | 1.02 (0.62 to 1.68) |
| IM | |||||
| 0–5 | 1 (0.03) | 11 (0.00) | / | / | |
| 6–10 | 5 (0.16) | 10 (0.00) | 3.75 (1.28 to 11.03) | 3.83 (1.30 to 11.26) | |
| 11–15 | 20 (0.64) | 55 (0.02) | 2.59 (1.51 to 4.43) | 2.60 (1.52 to 4.45) | |
| 16–20 | 30 (0.95) | 62 (0.03) | 3.55 (2.28 to 5.53) | 3.60 (2.31 to 5.62) | |
| 21–30 | 11 (0.35) | 32 (0.01) | 2.80 (1.41 to 5.56) | 2.78 (1.40 to 5.54) |
Bold text indicates results where the 95% CI does not cross 1.00.
*Model 1: adjusted for matching variables; model 2: adjusted for matching variables and IM; model 3: adjusted for matching variables, IM and education. In all models, the OR is comparing having a diagnosis within the age group with not having a diagnosis in the age group.
†Case definition 1: at least one MS diagnosis over age 30 years from the PR or MSR.
‡Case definition 2: two or more MS diagnoses over age 30 years from the PR or diagnosis in the MSR.
Cont, controls; IM, infectious mononucleosis; MSR, Multiple Sclerosis Register; n, total individuals in group; PR, National Patient Register.