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091 The impact of device-assisted therapy initiation on the gut microbiome in Parkinson’s disease
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  1. Michal Lubomski1,2,
  2. Xiangnan Xu3,
  3. Andrew J Holmes4,
  4. Jean Yang3,
  5. Carolyn M Sue1,2 and
  6. Ryan L Davis1
  1. 1Department of Neurogenetics, Kolling Institute, University of Sydney and Royal North Shore Hospital, Sydney, NSW, Australia
  2. 2Neurology Department, Royal North Shore Hospital, St Leonards, NSW, Australia
  3. 3School of Mathematics and Statistics. Sydney Precision Bioinformatics, University of Sydney, Camperdown, NSW, Australia
  4. 4School of Life and Environmental Sciences, The Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia

Abstract

Objectives Several studies have evaluated the impact of oral medication on the gut microbiome (GM) in Parkinson’s disease (PD). However, the impact of PD device-assisted therapies (DAT) on the GM remains to be investigated. We profiled acute temporal GM stability around the initiation of PD DAT.

Methods The GM of 21 PD patients initiating either Deep Brain Stimulation (DBS) or levodopa-carbidopa intestinal gel (LCIG) were compared to 10 spousal healthy control (HC) subjects. 16S amplicon sequencing of the V3-V4 region of stool bacterial DNA was used to compare temporal GM stability between groups and with clinical outcome measures, including disease alternations relative to therapy initiation. GM response to therapy in the PD group was assessed by comparing pre-therapy (-2 and 0 weeks) with post-therapy initiation timepoints (+2 and +4 weeks) and HCs at baseline (0 weeks).

Results Altered GM compositions were noted between the PD and HC groups at various taxonomic levels, including specific differences for DBS and LCIG therapies. Beta diversity changes were also identified across the 4 week post-treatment initiation period, implying a therapy-effect on the GM.

Conclusions We present the first acute longitudinal assessment of GM response to PD DAT. The pre-treatment PD-specific GM (consistent with previous studies) was altered following DAT initiation, indicating DATs have a modulatory impact on the GM in PD.

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