Abstract
Inflammatory demyelinating diseases, resulting in immune mediated destruction of myelin sheaths surrounding axons, can affect both the central (CNS) and peripheral (PNS) nervous systems. Their clinical course can be acute and monophasic such as in Guilliane Barre syndrome and acute disseminated encephalomyelitis, or chronic and relapsing as in chronic inflammatory demyelinating polyneuropathy and multiple sclerosis, depending on localisation to the PNS or CNS. Despite a common pathophysiological outcome – i.e. destruction of myelin – co-occurrence of peripheral and central demyelinating disorders in a single individual is rare. Herein we present a patient diagnosed with both MS and CIDP. The case raises the possibility of a common immunopathogenic process, which may have important implications for treatment.
