TY - JOUR T1 - Clinical and magnetic resonance study of a case of subacute sclerosing panencephalitis treated with ketogenic diet JF - BMJ Neurology Open JO - BMJ Neurol Open DO - 10.1136/bmjno-2021-000176 VL - 3 IS - 2 SP - e000176 AU - Mariarosaria Valente AU - Ilaria Del Negro AU - Daniele Bagatto AU - Riccardo Garbo AU - Christian Lettieri AU - Andrea Bernardini AU - Annacarmen Nilo AU - Maria Rosaria Peri AU - Davide Pecori AU - Gian Luigi Gigli Y1 - 2021/07/01 UR - http://neurologyopen.bmj.com/content/3/2/e000176.abstract N2 - Background Subacute sclerosing panencephalitis is a progressive neurodegenerative disorder caused by a latent and mutant measles virus which is extremely rare in developed countries. The lack of effective treatments leads to the research of other anti-inflammatory and neuroprotective treatments.Case Here we present a case of a 17-year-old patient affected by subacute sclerosing panencephalitis who manifest a dramatic improvement in neurological and general clinical conditions, as well as an arrest in the progression of demyelinating process in the central nervous system, after the beginning of a high ratio ketogenic diet.Conclusions Given its anti-inflammatory, antioxidant and metabolic effects, we believe that ketogenic diet utilisation could be a rational approach, can be considered a safe add-on therapy, carrying on with only a minimal risk of adverse effects or interactions.The data that support the findings of this short report are available on request from the corresponding author (IDN). ER -