TY - JOUR T1 - Longitudinal changes of early motor and cognitive symptoms in progressive supranuclear palsy: the OxQUIP study JF - BMJ Neurology Open JO - BMJ Neurol Open DO - 10.1136/bmjno-2021-000214 VL - 4 IS - 1 SP - e000214 AU - Marta F Pereira AU - Tim Buchanan AU - Günter U Höglinger AU - Marko Bogdanovic AU - George Tofaris AU - Simon Prangnell AU - Nagaraja Sarangmat AU - James J FitzGerald AU - Chrystalina A Antoniades Y1 - 2022/01/01 UR - http://neurologyopen.bmj.com/content/4/1/e000214.abstract N2 - Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative condition characterised by a range of motor and cognitive symptoms. Very little is known about the longitudinal change in these symptoms over time. Moreover, the effectiveness of clinical scales to detect early changes in PSP is still a matter of debate.Objective We aimed to determine longitudinal changes in PSP features using multiple closely spaced follow-up time points over a period of 2 years.Methods28 healthy control and 28 PSP participants, with average time since onset of symptoms of 1.9 years, were prospectively studied every 3 months for up to 24 months. Changes from baseline scores were calculated at each follow-up time point using multiple clinical scales to identify longitudinal progression of motor and cognitive symptoms.Results The Montreal Cognitive Assessment, but not the Mini-Mental State Examination, detected cognitive decline at baseline. Both scales revealed poor longitudinal sensitivity to clinical change in global cognitive symptoms. Conversely, the Movement Disorders Society Unified Parkinson’s disease Rating Scale – part III and the PSP Rating Scale (PSPRS) reliably detected motor decline less than 2 years after disease onset. The ‘Gait/Midline’ PSPRS subscore consistently declined over time, with the earliest change being observed 6 months after baseline assessment.Conclusion While better cognitive screening tools are still needed to monitor cognitive decline in PSP, motor decline is consistently captured by clinical rating scales. These results support the inclusion of multiple follow-up time points in longitudinal studies in the early stages of PSP.Data are available on reasonable request. Data may be made available after reasonable request if appropriate. ER -