TY - JOUR T1 - Video head impulse testing to differentiate vestibular neuritis from posterior circulation stroke in the emergency department: a prospective observational study JF - BMJ Neurology Open JO - BMJ Neurol Open DO - 10.1136/bmjno-2022-000284 VL - 4 IS - 1 SP - e000284 AU - James Orton Thomas AU - Angelos Sharobeam AU - Abhay Venkat AU - Christopher Blair AU - Nese Ozalp AU - Zeljka Calic AU - Peter Wyllie AU - Paul M Middleton AU - Miriam Welgampola AU - Dennis Cordato AU - Cecilia Cappelen-Smith Y1 - 2022/05/01 UR - http://neurologyopen.bmj.com/content/4/1/e000284.abstract N2 - Background and aims Vertigo is a common presentation to the emergency department (ED) with 5% of presentations due to posterior circulation stroke (PCS). Bedside investigations such as the head impulse test (HIT) are used to risk stratify patients, but interpretation is operator dependent. The video HIT (v-HIT) provides objective measurement of the vestibular-ocular-reflex (VOR) and may improve diagnostic accuracy in acute vestibular syndrome (AVS). We aimed to evaluate the use of v-HIT as an adjunct to clinical assessment to acutely differentiate vestibular neuritis (VN) from PCS.Methods 133 patients with AVS were consecutively enrolled from the ED of our comprehensive stroke centre between 2018 and 2021. Patient assessment included a targeted vestibular history, HINTs examination (Head Impulse, Nystagmus and Test of Skew), v-HIT and MRI>48 hours after symptom onset. The HINTS/v-HIT findings were analysed and compared between VN, PCS and other cause AVS. Clinical course, v-HIT and MRI findings were used to determine diagnosis.Results Final diagnosis was VN in 40%, PCS 15%, migraine 16% and other cause AVS 29%. PCS patients were older than VN patients (mean age 68.5±10.6 vs 60.1±14.2 years, p=0.14) and had more cardiovascular risk factors (3 vs 2, p=0.002). Mean VOR gain was reduced (<0.8) in ipsilateral horizontal and (<0.7) anterior canals in VN but was normal in PCS, migraine and other cause AVS. V-HIT combined with HINTs was 89% sensitive and 96% specific for a diagnosis of VN.ConclusionsV-HIT combined with HINTs is a reliable tool to exclude PCS in the ED.Data are available on reasonable request. Please contact corresponding author for requests for data sharing. ER -