Table 1

Baseline characteristics and imaging findings of patients who had acute ischaemic stroke with leukoaraiosis (LA) categorised by presence of symptomatic intracerebral haemorrhage (sICH) after intravenous thrombolytic therapy

FactorsNo sICH, n=459sICH, n=45P value
Mean (SD) age, years64.3 (13.3)70.2 (9.6)0.002
Male sex257 (56.0)20 (44.4)0.137
Comorbid diseases
 Hypertension234 (51.0)26 (57.8)0.380
 Dyslipidaemia115 (25.1)7 (15.6)0.158
 Diabetes mellitus127 (27.7)18 (40)0.080
 Atrial fibrillation and flutter122 (26.6)18 (40)0.050
 Myocardial infarction32 (7)3 (6.7)0.999
Previous antiplatelet therapy120 (26.1)21 (46.7)0.003
Previous anticoagulant therapy12 (2.61)3 (6.67)0.140
Mean systolic blood pressure (SD), mm Hg149.6 (28.7)156.0 (26.1)0.103
Mean diastolic blood pressure (SD), mm Hg84.9 (16.2)85.9 (15.6)0.515
Median (range) NIHSS9 (1–39)16 (4–27)<0.001
Types of stroke
 Large-artery atherosclerosis135 (29.4)22 (48.9)0.007
 Cardioembolism145 (31.6)18 (40)0.248
 Small-vessel occlusion178 (38.8)5 (11.1)<0.001
Imaging
 LA findings0.001
  No LA188 (41.0)8 (17.8)
  LA grade I–II238 (51.8)29 (64.4)
  LA grade III–IV33 (7.2)8 (17.8)
 ASPECT Score<0.001
  7–10368 (80.2)22 (48.9)
  4–664 (13.9)16 (35.5)
  <427 (5.9)17 (15.6)
 Hyperdense artery sign114 (24.8)26 (57.8)<0.001
  • Data presented as number (%) unless indicated otherwise.

  • ASPECT Score, The Alberta Stroke Programme Early CT Score; NIHSS, National Institutes of Health Stroke Scale.