Table 3

National COVID-19 clinical evidence Taskforce recommendations for chemoprophylaxis in patients with COVID-1942

PopulationChemoprophylaxis recommendation
Adults with moderate COVID-19
  • Prophylactic anticoagulants, preferably low molecular weight heparins for example, enoxaparin 40 mg or dalteparin 5000 IU once daily

  • If contraindicated, unfractionated heparin or renally adjusted doses of low-molecular-weight heparins may be used for example, enoxaparin 20 mg or dalteparin 2500 IU once daily

Severe or critical COVID-19, without contraindications
  • Consider increased prophylactic dosing, preferably low molecular weight heparins, for example, enoxaparin 40 mg or dalteparin 5000 IU two times per day

  • In presence of acute kidney injury (creatinine clearance <30 mL/min), unfractionated heparin or renally adjusted doses of low-molecular-weight heparins may be used, for example, enoxaparin 40 mg or dalteparin 5000 IU once daily

All patients
  • Chemoprophylaxis should be combined with non-pharmacological measures such as rehydration

  • Where VTE chemoprophylaxis is contraindicated, mechanical prophylaxis like intermittent pneumatic compression should be used

  • VTE, venous thromboembolism.