Safety outcomes based on treatment group.
| Outcome | Phenytoin, n=52 | Lacosamide, n=18 | P value |
| Hypotension, n (%)* | 26 (55.3) | 5 (35.7) | 0.198 |
| Mean decrease in systolic blood pressure±SD, mm Hg | 20.9±18.5 | 9.8±11.5 | 0.019 |
| LFT elevation, n (%)† | 5 (29.4) | 0 (0) | 0.539 |
| PR interval prolongation, n (%)‡ | 0 (0) | 1 (6.7) | 0.246 |
| Bradycardia, n (%)§ | 5 (9.8) | 0 (0) | 0.316 |
*n=47 and n=14, respectively.
†n=17 and n=3, respectively.
‡n=46 and n=15, respectively.
§n=51 and n=18, respectively.