Patients presenting with hoarseness/dysphonia and their SOD1 gene status
| Reference | Mutation/FH | Laryngoscopic findings | Disease presentation | Survival |
| Fukae et al2 | SOD1 (I 149 T) | Bilat VCAbdP Asymmetric | Hoarseness followed 10 months later by dysphagia/fasciculations | Not stated |
| Origone et al4 | SOD1 (Gly 147 Ser) | Bilat VCAbdP R then L cord after 3 weeks | Episodic dyspnoea and hoarseness, stridor | 8 months |
| Tan et al5 | SOD1 (Asp 101 Tyr) | Bilat VCP unspecified | Hoarseness for 3 months, followed by dysphagia | 11 months |
| Bigliardi et al8 | No FH | Bilat VCAbdP | 6 month history of hoarseness. Admitted with dyspnoea and stridor, no dysarthria/dysphagia | Not stated |
| Levian and Gupta14 | No FH | Bilat VCAbdP | 4 month history of hoarseness/dysphonia | Not stated |
| Hermann et al3 | SOD1 (I 113 F) | Bilat VCP unspecified laryngospasm | Hoarseness for 5 weeks and rapid involvement of other areas | 15 months |
| Our case | SOD1 (Val 149 Gly) | Unilateral VCAdd P | Hoarseness/dysphonia | 20 months |
ALS, amyotrophic lateral sclerosis; FH, family history of MND/ALS; MND, motor neuron disease; SOD1, superoxide dismutase 1; VCAbdP, vocal cord abductor paresis or paralysis; VCAddP, vocal cord adductor paresis or paralysis; VCP, unspecified vocal cord paresis or paralysis.