Table 1

Summary of adverse events from published case series

Study	Cases (n)	Duration (years)	Postoperative window examined	Overall adverse events (%)	Mortality (%)	ICH (symptomatic) (%)	Seizure (%)	Stroke (%)	Transient neurology (%)	Postoperative confusion (%)	Infection (%)	Hardware issue (%)
Engel et al 20186	123	4	NS	14.6	NS	1.6 (1.6)	NS	NS	1.6	NS	3.3	NS
Chen et al 20177	284	3	NS	NS	NS	1.4	1.2	0	NS	5	1.1	0.6
Fernández-Pajarin et al 20178	249	16	28 days	NS	NS	3.1 (1.6)	1.9	0.3	NS	NS	1.6	0.9
Tonge et al 2015*9	220	15	30 days	NS	0.045	1.81 (1.81)	0.9	NS	NS	NS	NS	NS
Levi et al 201510	107	12	90 days	6.54	0	4.7	0	NS	13.15	NS	2.9	0
Verla et al 2015†11	661	9	90 days	7.1	0	1.5	NS	NS	NS	NS	3	1.4
Fenoy and Simpson 2014*12	728	8	14 days	NS	NS	5 (1.1)	0.7	0.4	1.7	1.9	3.2‡	3.1‡
Doshi 201113	153	10	Long term	15.6	NS	1.31 (1.31)	NS	NS	0.65	3.92	4.5	2.61
Voges et al 2006*14	262	7	30 days	4.2	NS	0.38 (0)	NS	NS	1.2	NS	1.5	1.9
Goodman et al 200615	100	4	NS	37	0	2	3	0.4	NS	13	5	2

Hardware issues include both electrode malposition and malfunction of the implantable pulse generator, extension leads and electrodes.
*Includes data on non-movement disorder indications for DBS.
†Database study.
‡Reported for a period of >14 days postoperatively.
DBS, deep brain stimulation; ICH, intracranial haemorrhage; NS, not specified.