Table 2
Enduring changes in scores in clinical measures with and without adjustment for multiple comparisons
| Scores | Subscores | Individual scores | P <0.05 | P <0.008 (after Bonferroni correction) | ||||||
| Earliest change in scores | ∆ value | SD | Effect size | Earliest change in scores | ∆ value | SD | Effect size | |||
| PSPRS total | 9 months | 4.59 | 8.43 | 0.54 | 15 months | 7.42 | 7.63 | 0.97 | ||
| History | 15 months | 2.50 | 3.09 | −0.81 | – | – | – | – | ||
| Mentation | – | – | – | – | – | – | – | |||
| Bulbar | 15 months | 1.06 | 7.02 | 0.79 | – | – | – | – | ||
| Ocular motor | 9 months | 2.00 | 3.298 | 0.61 | 12 months | 2.38 | 3.01 | 0.79 | ||
| Limbs | – | – | – | – | – | – | – | – | ||
| Gait/Midline | – | – | – | – | 6 months | 2.00 | 4.92 | 0.69 | ||
| MDS-UPDRS-III | 6 months | 5.86 | 10.59 | 0.55 | 12 months | 11.75 | 12.31 | 0.95 | ||
| Schwab and England scale | 3 months | −10.00 | 10.87 | 0.70 | ||||||
∆value (∆visit score - ∆baseline); Effect size: Cohen’s d for parametric analysis and
for non-parametric analysis.MDS-UPDRS-III, Movement Disorders Society Unified Parkinson’s disease Rating Scale part III; PSPRS, Progressive Supranuclear Palsy Rating Scale.
