Demographics and baseline (visit 1) scores for HC and PSP participants
| HC (n=28) Mean (range) | PSP (n=28) Mean (range) | P value | |
| Age, years | 66.2 (56–72) | 69.2 (52–88) | 0.134* |
| Gender, M/F | 10/18 | 15/12 | 0.140† |
| Age at onset of symptoms | 65.9 (51–86) | ||
| Time since diagnosis, years | NA | 1.2 (0.1–5.10) | |
| Time since onset of symptoms to visit, years | NA | 1.9 (0.2–6.3) | |
| Education, years | 15.4 (12–17) | 14.0 11–20) | 0.017* |
| LEUs, mg | NA | 345.5 (50–800) | |
| Motor assessment | |||
| MDS-UPDRS-III | 2.25 (0–11) | 44.4 (21–72) | 0.000* |
| PSPRS | 38.9.1 (19–64) | ||
| H&Y | 3.0 (1–4) | ||
| Functional assessment | |||
| Schwab and England scale | 71.1 (20–90) | ||
| Neuropsychological assessment | |||
| MMSE | 29.1 (26–30) | 26.0 (20–30) | 0.000*‡ |
| MoCA | 28.0 (26–30) | 22.4 (12–30) | 0.000*‡ |
| Fluency, phonemic | 46.3 (27–65) | 19.9 (6–50) | 0.000*‡ |
| Fluency, Semantic | 42.0 (33–55) | 21.8 (6–41) | 0.000*‡ |
*Mann-Whitney U test.
†χ2 test.
‡Corrected for ‘Education’.
F, female; HC, healthy controls; H&Y, Hoehn and Yahr Scale; LEU, Levodopa equivalent unit; M, male; MDS-UPDRS-III, Movement Disorders Society Unified Parkinson’s Disease Rating Scale – part III; MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment; NA, not applicable; PSP, Progressive Supranuclear Palsy; PSPRS, Progressive Supranuclear Palsy Rating Scale.