Table 1

Demographics and baseline (visit 1) scores for HC and PSP participants

HC (n=28)
Mean (range)
PSP (n=28)
Mean (range)
P value
Age, years66.2 (56–72)69.2 (52–88)0.134*
Gender, M/F10/1815/120.140†
Age at onset of symptoms65.9 (51–86)
Time since diagnosis, yearsNA1.2 (0.1–5.10)
Time since onset of symptoms to visit, yearsNA1.9 (0.2–6.3)
Education, years15.4 (12–17)14.0 11–20)0.017*
LEUs, mgNA345.5 (50–800)
Motor assessment
MDS-UPDRS-III2.25 (0–11)44.4 (21–72)0.000*
PSPRS38.9.1 (19–64)
H&Y3.0 (1–4)
Functional assessment
Schwab and England scale71.1 (20–90)
Neuropsychological assessment
MMSE29.1 (26–30)26.0 (20–30)0.000*‡
MoCA28.0 (26–30)22.4 (12–30)0.000*‡
Fluency, phonemic46.3 (27–65)19.9 (6–50)0.000*‡
Fluency, Semantic42.0 (33–55)21.8 (6–41)0.000*‡
  • *Mann-Whitney U test.

  • †χ2 test.

  • ‡Corrected for ‘Education’.

  • F, female; HC, healthy controls; H&Y, Hoehn and Yahr Scale; LEU, Levodopa equivalent unit; M, male; MDS-UPDRS-III, Movement Disorders Society Unified Parkinson’s Disease Rating Scale – part III; MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment; NA, not applicable; PSP, Progressive Supranuclear Palsy; PSPRS, Progressive Supranuclear Palsy Rating Scale.