Associations of stenosis and outcomes
| Total | Events, n (%) | Unadjusted | P value | Adjusted | P value | ||
| OR (95% CI) | OR (95% CI) | ||||||
| NIHSS score ≥4 | Non-PAS | 2210 | 1015 (45.93) | Reference | – | Reference | – |
| PAS | 680 | 364 (53.53) | 1.356 (1.142 to 1.611) | 0.0005 | 1.262 (1.058 to 1.505) | 0.0097 | |
| 3 months | |||||||
| mRS score 3–6* | Non-PAS | 2210 | 207 (9.50) | Reference | – | Reference | – |
| PAS | 680 | 97 (14.46) | 1.611 (1.244 to 2.086) | 0.0003 | 1.200 (0.902 to 1.598) | 0.2112 | |
| Ischaemic stroke recurrence | Non-PAS | 2210 | 87 (3.94) | Reference | – | Reference | – |
| PAS | 680 | 65 (9.56) | 2.475 (1.795 to 3.414) | <0.0001 | 2.266 (1.631 to 3.149) | <0.0001 | |
| Composite vascular events | Non-PAS | 2210 | 91 (4.12) | Reference | – | Reference | – |
| PAS | 680 | 69 (10.15) | 2.516 (1.840 to 3.441) | <0.0001 | 2.306 (1.674 to 3.178) | <0.0001 | |
| 1 year | |||||||
| mRS score 3–6* | Non-PAS | 2210 | 172 (7.97) | Reference | – | Reference | – |
| PAS | 680 | 88 (13.27) | 1.767 (1.345 to 2.322) | <0.0001 | 1.266 (0.939 to 1.708) | 0.1225 | |
| Ischaemic stroke recurrence | Non-PAS | 2210 | 137 (6.20) | Reference | – | Reference | – |
| PAS | 680 | 88 (12.94) | 2.163 (1.655 to 2.827) | <0.0001 | 2.054 (1.561 to 2.702) | <0.0001 | |
| Composite vascular events | Non-PAS | 2210 | 157 (7.10%) | Reference | – | Reference | – |
| PAS | 680 | 97 (14.26%) | 2.090 (1.623 to 2.693) | <0.0001 | 1.983 (1.530 to 2.570) | <0.0001 | |
Adjustment for baseline characteristics includes age, sex, history of hypertension, history of diabetes and smoking.
*(mRS) Adjustment for baseline characteristics includes age, sex, history of hypertension, history of diabetes, smoking and NIHSS score.
CI, confidence interval; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; OR, odds ratios; PAS, parent artery stenosis.