Table 1

Patient-reported outcome measures used in AubPRO

ScaleItemsDomainsTime frameScoring
Treatment Satisfaction Questionnaire for Medication, version 1.46
Assesses overall satisfaction or dissatisfaction with their medication		14Effectiveness (3 questions)
Side effects (5 questions)
Convenience (3 questions)
Global satisfaction (3 questions)		Current medication: past 2–3 weeks, or since last use

  •  Likert scale 1–7

  •  Domain scores range from 0 to 100, higher scores indicate greater treatment satisfaction within that domain

Multiple Sclerosis Performance Scale18
Assesses multidimensional disability in patients with MS		8Mobility, bowel/bladder, fatigue, sensory, vision, cognition, spasticity, hand function
Additional subscales:
pain, depression and tremor/coordination		Current vs before MS diagnosis

  •  Likert scale 0–6 (mobility domain)

  •  Likert scale 0–5 (all other domains)

  •  Ordinal summary index across all 8 domains, total scores range from 0 to 41, higher scores indicate worse disability

  •  With additional subscales, the total scores range from 0 to 66, higher scores indicate worse symptoms

Multiple Sclerosis Impact Scale, version 219 20
Assesses the impact of MS on both physical and psychological well-being		29Physical (20 items)
Psychological (9 items)		Past 2 weeks

  •  Likert scale 1–4

  •  Summary scores in each domain are calculated by addition of individual scores and transformation into a 0–100 point scale, higher scores indicate higher (negative) impact

Multiple Sclerosis Walking Scale, version 221 22
Assesses patients’ perception of the impact of MS on their walking ability		12Walking (12 items)Past 2 weeks

  •  Likert scale 1–5

  •  Summary scores are calculated by addition of individual scores and transformation into a 0–100 point scale, higher scores indicate higher (negative) impact on walking

Health-Related Productivity Questionnaire, version 223
Measures the impact of disease on productivity across employed work and household chores		9Employment status (1 item)
Work (3 items)
Household chores (3 items)
Workforce participation (2 items)		Employment status: current
Work/chores:
in the last week
Workforce participation:
since diagnosis

  •  Enables multiple calculations, including the number of hours lost, per cent of the patient’s scheduled work that is lost due to absenteeism and lost due to presenteeism, and overall per cent of work lost specifically to workplace and to household

  • MS, multiple sclerosis.