Patient group | CVT | IVT only | MT only | IVT+MT |
Proportion of patient observations used for predictive modelling (n) | 33.8% (18 407) | 61.7% (5 184) | 42.1% (235) | 58.8% (339) |
Age, average years (difference in years*) | 78.4 (+0.9) | 76.0 (+1.6) | 73.9 (+2.2) | 71.3 (+1.6) |
NIHSS, median score (score difference*) | 4 (+1) | 7 (±0) | 16 (+2) | 16 (+1) |
OTT time for IVT, median time in minutes (difference in minutes*) | N/A (N/A) | 201 (–2) | N/A (N/A) | 180 (±0) |
OTT time for MT, median time in minutes (difference in minutes*) | N/A | N/A | 350 (–20) | 378 (–2) |
mRS-90d, average score (score difference*) | 3.62 (–0.03) | 3.45 (±0.00) | 4.27 (0.15) | 3.73 (+0.03) |
Maximum likelihood parameter estimates of fitted GLMs: | ||||
Age (CVT), age∧2 (IVT only, MT only, IVT+MT) (likelihood ratio 95% confidence limits) | 0.0388 (0.0385 to 0.0391) | 0.0004 (0.0004 to 0.0004) | 0.0006 (0.0005 to 0.0006) | 0.0004 (0.0004 to 0.0005) |
NIHSS score (CVT), NIHSS score∧2 (IVT only, MT only, IVT+MT) (likelihood ratio 95% confidence limits) | 0.0960 (0.0932 to 0.0987) | 0.0033 (0.0031 to 0.0035) | 0.0017 (0.0006 to 0.0027) | 0.0024 (0.0016 to 0.0032) |
IVTOTT (likelihood ratio 95% confidence limits) | N/A (N/A) | 0.0022 (0.0019 to 0.0025) | N/A | 0.0022 (0.0005 to 0.0038) |
MTOTT (likelihood ratio 95% confidence limits) | N/A (N/A) | N/A (N/A) | 0.0014 (0.0007 to 0.0021) | 0.0010 (0.0001 to 0.0018) |
Dispersion, scale (likelihood ratio 95% confidence limits) | 1.13 (1.1156 to 1.1386) | 1.18 (1.1622 to 1.2078) | 1.48 (1.3598 to 1.6296) | 1.32 (1.2311 to 1.4312) |
Goodness of fit measures | ||||
Coefficient of determination (R2) | 0.92 | 0.90 | 0.89 | 0.89 |
Root mean square error | 0.91 | 0.93 | 1.19 | 1.10 |
Mean arctangent absolute percentage error | 27.34 | 28.15 | 29.07 | 30.19 |
*Difference compared with the corresponding value for the entire patient group.
AIS, acute ischaemic stroke; CVT, conservative therapy; GLM, generalised linear model; IVT, intravenous thrombolysis; mRS, modified Rankin Scale; MT, mechanical thrombectomy; NIHSS, National Institutes of Health Stroke Scale; OTT, onset-to-treatment time.