ReviewDifferentiating drug-induced parkinsonism from Parkinson's disease: An update on non-motor symptoms and investigations
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Editor's comment: Differentiating drug-induced parkinsonism (DIP) from Parkinson's disease (PD) can be a difficult and frustrating exercise for both patient and physician. To make matters even more difficult, individuals with incipient PD may be more prone to develop DIP because of already reduced dopaminergic reserve. Thus, this very useful review by Brigo and colleagues cogently summarizes the information available regarding the usefulness of various approaches and procedures in separating these two entities. They describe the value of some nonmotor features of PD, especially olfactory dysfunction, in distinguishing between PD and DIP. They also provide very useful information on which procedures are useful (DaT-scan and MIBG scanning) and which do not seem to be (transcranial sonography of the substantia nigra) in making this differentiation.
Ronald F. Pfeiffer, Editor-in-Chief Department of Neurology, University of Tennessee HSC, 855 Monroe Avenue, Memphis, TN 38163, USA.
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These authors contributed equally to the manuscript.