Regular ArticleAgeing: definitions, mechanisms and the magnitude of the problem
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2019, Chemistry and Physics of LipidsCitation Excerpt :A wide number of theories have been proposed over the past decades (Medvedev, 1990), ranging from the accumulation of damage to the biological programmed aging. It is widely accepted, however, that theories from both categories are not necessarily exclusive, and aging is regarded as a complex, multifactorial process driven by both intrinsic (genetic) and extrinsic (environmental) factors (Balcombe and Sinclair, 2001; Medvedev, 1990). Recent reviews of the aging process integrate many different theories in a global perspective.
Combined exercise is a modality for improving insulin resistance and aging-related hormone biomarkers in elderly Korean women
2018, Experimental GerontologyCitation Excerpt :DHEA-S, a steroid hormone secreted by the adrenal gland in an esterified form, is converted to androgen, a male hormone, and estrogen, a female hormone, in the peripheral tissues. A reduction in DHEA-S levels causes increased susceptibility to cancer, atherosclerosis, brain damage, and insulin resistance (Balcombe and Sinclair, 2001; Kell, 2011). During menopause, a unique transition stage of the endocrine system, the estrogen level decreases, thus causing a reduction in the fat-free mass index and BMR (Munsell et al., 2014; Lovejoy et al., 2008).
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All Correspondence to: Dr N.R. Balcombe, 1 Brewers Close, Binley, Coventry, CV3 2UP, UK, Tel: 07968 111 470; E-mail: [email protected]