Abstract
We report on 20 natalizumab-treated patients with multiple sclerosis who developed laboratory-confirmed central nervous system (CNS) herpesvirus infections. In addition to progressive multifocal leukoencephalopathy, other CNS opportunistic infections have been rarely reported during natalizumab treatment. We encourage heightened awareness due to the risk for serious outcomes.
Keywords:
HSV; VZV; encephalitis; meningitis; natalizumab.
MeSH terms
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Adult
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Antibodies, Monoclonal, Humanized / adverse effects*
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Antibodies, Monoclonal, Humanized / therapeutic use
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Encephalitis, Herpes Simplex / chemically induced*
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Encephalitis, Varicella Zoster / chemically induced*
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Female
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Herpesvirus 3, Human / isolation & purification
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Humans
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Male
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Meningitis, Viral / chemically induced*
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Middle Aged
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Multiple Sclerosis / drug therapy
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Multiple Sclerosis / virology
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Natalizumab
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Simplexvirus / isolation & purification
Substances
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Antibodies, Monoclonal, Humanized
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Natalizumab