Peripheral nerve regeneration: experimental strategies and future perspectives

Alessandro Faroni; S Atefeh Mobasseri; Paul J Kingham; Adam J Reid

doi:10.1016/j.addr.2014.11.010

Peripheral nerve regeneration: experimental strategies and future perspectives

Adv Drug Deliv Rev. 2015 Mar:82-83:160-7. doi: 10.1016/j.addr.2014.11.010. Epub 2014 Nov 14.

Authors

Alessandro Faroni¹, S Atefeh Mobasseri², Paul J Kingham³, Adam J Reid⁴

Affiliations

¹ Blond McIndoe Laboratories, Tissue Injury and Repair, Institute of Inflammation and Repair, University of Manchester, Manchester, UK.
² Blond McIndoe Laboratories, Tissue Injury and Repair, Institute of Inflammation and Repair, University of Manchester, Manchester, UK; Materials Science Centre, School of Materials, The University of Manchester, Manchester, UK.
³ Section for Anatomy, Department of Integrative Medical Biology, Umeå University, Umeå, Sweden.
⁴ Blond McIndoe Laboratories, Tissue Injury and Repair, Institute of Inflammation and Repair, University of Manchester, Manchester, UK; Department of Plastic Surgery & Burns, University Hospital of South Manchester, Manchester, UK. Electronic address: adam.reid@manchester.ac.uk.

PMID: 25446133
DOI: 10.1016/j.addr.2014.11.010

Abstract

Peripheral nerve injuries represent a substantial clinical problem with insufficient or unsatisfactory treatment options. This review summarises all the events occurring after nerve damage at the level of the cell body, the site of injury and the target organ. Various experimental strategies to improve neuronal survival, axonal regeneration and target reinnervation are described including pharmacological approaches and cell-based therapies. Given the complexity of nerve regeneration, further studies are needed to address the biology of nerve injury, to improve the interaction with implantable scaffolds, and to implement cell-based therapies in nerve tissue engineering.

Keywords: Muscle denervation; Neuronal survival; Peripheral nerve regeneration; Reinnervation; Scaffold; Stem cell.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Guided Tissue Regeneration / methods*
Humans
Nerve Regeneration / drug effects
Nerve Regeneration / physiology*
Peripheral Nerve Injuries / physiopathology
Peripheral Nerve Injuries / surgery*
Tissue Engineering / methods*
Tissue Engineering / trends

Grants and funding

II-LA-0313-20003/DH_/Department of Health/United Kingdom