Poststroke cognitive impairment and dementia (PSCID) is a major source of morbidity and
mortality after stroke worldwide. PSCID occurs as a consequence of ischemic stroke …

Background Stroke thrombolysis with alteplase is currently recommended 0–4· 5 h after
stroke onset. We aimed to determine whether perfusion imaging can identify patients with …

Cerebral small vessel disease (SVD) is common during ageing and can present as stroke,
cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently …

Importance There are limited efficacious treatments for Alzheimer disease. Objective To
assess efficacy and adverse events of donanemab, an antibody designed to clear brain …

Damage to specific brain circuits can cause specific neuropsychiatric symptoms.
Therapeutic stimulation to these same circuits may modulate these symptoms. To determine …

Interest in dementia has increased over the past few decades. Stroke is an important cause
of cognitive problems. The term vascular cognitive impairment is now used to describe …

Alzheimer's disease is increasingly considered a large-scale network disconnection
syndrome, associated with progressive aggregation of pathological proteins, cortical …

Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with
about a third of cases being genetic. Most of this genetic component is accounted for by …

Importance Intravenous thrombolysis with tenecteplase improves reperfusion prior to
endovascular thrombectomy for ischemic stroke compared with alteplase. Objective To …

Accurate lesion segmentation is critical in stroke rehabilitation research for the quantification
of lesion burden and accurate image processing. Current automated lesion segmentation …