User profiles for "author:James McFadyen"
James McFadyenVerified email at monash.edu Cited by 2455 |
The emerging threat of (micro) thrombosis in COVID-19 and its therapeutic implications
JD McFadyen, H Stevens, K Peter - Circulation research, 2020 - Am Heart Assoc
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …
and the ensuing global pandemic has presented a health emergency of unprecedented …
Current and future antiplatelet therapies: emphasis on preserving haemostasis
JD McFadyen, M Schaff, K Peter - Nature Reviews Cardiology, 2018 - nature.com
Antiplatelet drugs, such as aspirin, P2Y12 antagonists, and glycoprotein (GP) IIb/IIIa
inhibitors, have proved to be successful in reducing the morbidity and mortality associated …
inhibitors, have proved to be successful in reducing the morbidity and mortality associated …
[HTML][HTML] Platelet-derived microvesicles in cardiovascular diseases
MTK Zaldivia, JD McFadyen, B Lim, X Wang… - Frontiers in …, 2017 - frontiersin.org
Microvesicles (MVs) circulating in the blood are small vesicles (100–1,000 nm in diameter)
derived from membrane blebs of cells such as activated platelets, endothelial cells, and …
derived from membrane blebs of cells such as activated platelets, endothelial cells, and …
[HTML][HTML] Dissociation of C-reactive protein localizes and amplifies inflammation: evidence for a direct biological role of C-reactive protein and its conformational …
JD McFadyen, J Kiefer, D Braig, J Loseff-Silver… - Frontiers in …, 2018 - frontiersin.org
C-reactive protein (CRP) is a member of the pentraxin superfamily that is widely recognized
as a marker of inflammatory reactions and cardiovascular risk in humans. Recently, a …
as a marker of inflammatory reactions and cardiovascular risk in humans. Recently, a …
[HTML][HTML] C-reactive protein, immunothrombosis and venous thromboembolism
C Dix, J Zeller, H Stevens, SU Eisenhardt… - Frontiers in …, 2022 - frontiersin.org
C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of
proteins and is often used in clinical practice as a marker of infection and inflammation …
proteins and is often used in clinical practice as a marker of infection and inflammation …
Platelets are not just for clots
JD McFadyen, ZS Kaplan - Transfusion medicine reviews, 2015 - Elsevier
Although the role of platelets as central mediators of hemostasis and thrombosis has been
the primary focus of research into platelet biology for more than a century, over the last …
the primary focus of research into platelet biology for more than a century, over the last …
C-reactive protein and its structural isoforms: an evolutionary conserved marker and central player in inflammatory diseases and beyond
JD McFadyen, J Zeller, LA Potempa… - … , lipoproteins and other …, 2020 - Springer
C-reactive protein (CRP) is an evolutionary highly conserved member of the pentraxin
superfamily of proteins. CRP is widely used as a marker of inflammation, infection and for …
superfamily of proteins. CRP is widely used as a marker of inflammation, infection and for …
Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases
J Zeller, B Bogner, JD McFadyen, J Kiefer… - Pharmacology & …, 2022 - Elsevier
C-reactive protein (CRP) is the prototypic acute-phase reactant that has long been
recognized almost exclusively as a marker of inflammation and predictor of cardiovascular …
recognized almost exclusively as a marker of inflammation and predictor of cardiovascular …
[HTML][HTML] The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function
JK Mountford, C Petitjean, HWK Putra… - Nature …, 2015 - nature.com
PI3KC2α is a broadly expressed lipid kinase with critical functions during embryonic
development but poorly defined roles in adult physiology. Here we utilize multiple mouse …
development but poorly defined roles in adult physiology. Here we utilize multiple mouse …
A randomized trial of nafamostat for Covid-19
SC Morpeth, B Venkatesh, JA Totterdell… - NEJM …, 2023 - evidence.nejm.org
Background Nafamostat mesylate is a potent in vitro antiviral agent that inhibits the host
transmembrane protease serine 2 enzyme used by severe acute respiratory syndrome …
transmembrane protease serine 2 enzyme used by severe acute respiratory syndrome …