CMAJ• NOV. 30, 1999; 161 (11) 1419 nation showed mild diffuse swelling of the cerebral
hemispheres with diffuse meningeal congestion. Histological examination revealed an …

Congenital brain tumors are rare, accounting for 0.5% to 4% of all pediatric brain tumors. A
10-year retrospective study based on autopsy and neurosurgical clinical reports with a …

Glioblastoma (GBM) is characterized by extensive cellular and genetic heterogeneity. Its
initial presentation as primary disease (pGBM) has been subject to exhaustive molecular …

Purpose: Clonal evolution of cancer may be regulated by determinants of stemness,
specifically self-renewal, and current therapies have not considered how genetic …

Medulloblastoma (MB) is defined by four molecular subgroups (Wnt, Shh, Group 3, Group 4)
with Wnt MB having the most favorable prognosis. Since prior reports have illustrated the …

Hemimegalencephaly (HME) is a developmental abnormality of the central nervous system,
identified by an abnormal increase in the size of one cerebral hemisphere. HME may …

Background Brain metastases are most common in adults with lung cancer, predicting
uniformly poor patient outcome, with a median survival of only months. Despite their …

Mechanistic insight into signaling pathways downstream of surface receptors has been
revolutionized with integrated cancer genomics. This has fostered current treatment …

The master regulatory gene Bmi1 modulates key stem cell properties in neural precursor
cells (NPCs), and has been implicated in brain tumorigenesis. We previously identified a …

We report a boy of East Indian origin, aged 2 years and 10 months, who died suddenly and
unexpectedly. Autopsy findings showed marked cerebral swelling with herniation and …