In discussions on intestinal protection, the protective capacity of mucus has not been very
much considered. The progress in the last years in understanding the molecular nature of …

The functional properties of glycoproteins are strongly influenced by their profile of
glycosylation, and changes in this profile are seen in malignancy. In mucin-type O-linked …

The epithelial mucin MUC1 is a high molecular weight membrane glycoprotein frequently
overexpressed and aberrantly glycosylated in adenocarcinoma. Mucins normally contain …

The Human Proteome Organisation Human Disease Glycomics/Proteome Initiative recently
coordinated a multi-institutional study that evaluated methodologies that are widely used for …

The colonic epithelial surface is protected by an inner mucus layer that the commensal
microflora cannot penetrate. We previously demonstrated that Entamoeba histolytica …

We have developed an expression system for the production of large quantities of
recombinant MUC1 mucin in CHO-K1 (Chinese-hamster ovary K1) cells. The extracellular …

Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors via its
B subunit (CTB). We have recently shown that in addition to the previously described …

The gel-forming mucins are large and heavily O-glycosylated proteins which build up mucus
gels. The recombinant production of full-length gel-forming mucins has not been possible to …

Tumors exploit several strategies to evade immune recognition, including the production of a
large number of immunosuppressive factors, which leads to reduced numbers and impaired …

Mucus forms an important protective barrier that minimizes bacterial contact with the colonic
epithelium. Intestinal mucus is organized in a complex network with several specific …