Comparison of clopidogrel monotherapy after 1 to 2 months of dual antiplatelet therapy with 12 months of dual antiplatelet therapy in patients with acute coronary …

H Watanabe, T Morimoto, M Natsuaki… - JAMA …, 2022 - jamanetwork.com
Importance Clopidogrel monotherapy after short dual antiplatelet therapy (DAPT) after
percutaneous coronary intervention (PCI) has not yet been fully investigated in patients with …

Mitochondrial ATP-Sensitive Potassium Channels Attenuate Matrix Ca2+ Overload During Simulated Ischemia and Reperfusion: Possible Mechanism of …

M Murata, M Akao, B O'Rourke, E Marbán - Circulation research, 2001 - Am Heart Assoc
Mitochondrial ATP-sensitive potassium (mitoKATP) channels play a key role in ischemic
preconditioning of the heart. However, the mechanism of cardioprotection remains …

[HTML][HTML] Antithrombotic therapy for atrial fibrillation with stable coronary disease

S Yasuda, K Kaikita, M Akao, J Ako… - … England Journal of …, 2019 - Mass Medical Soc
Background There are limited data from randomized trials evaluating the use of
antithrombotic therapy in patients with atrial fibrillation and stable coronary artery disease …

Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes

Y Teshima, M Akao, SP Jones, E Marbán - Circulation research, 2003 - Am Heart Assoc
Uncoupling proteins (UCPs) are located in the mitochondrial inner membrane and partially
dissipate the transmembrane proton electrochemical gradient. UCP2 is expressed in various …

Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells

M Akao, A Ohler, B O'Rourke, E Marbán - Circulation Research, 2001 - Am Heart Assoc
Mitochondria can either enhance or suppress cell death. Cytochrome c release from
mitochondria and depolarization of the mitochondrial membrane potential (ΔΨ) are crucial …

A Novel SCN5A Gain-of-Function Mutation M1875T Associated With Familial Atrial Fibrillation

T Makiyama, M Akao, S Shizuta, T Doi… - Journal of the American …, 2008 - jacc.org
Objectives: This study describes a novel heterozygous gain-of-function mutation in the
cardiac sodium (Na+) channel gene, SCN5A, identified in a Japanese family with lone atrial …

[HTML][HTML] Current status of clinical background of patients with atrial fibrillation in a community-based survey: the Fushimi AF Registry

M Akao, YH Chun, H Wada, M Esato, T Hashimoto… - Journal of …, 2013 - Elsevier
BACKGROUND: Atrial fibrillation (AF) increases the risks of stroke and death, and the
prevalence of AF is increasing significantly. Until recently, warfarin was the only oral …

[HTML][HTML] Low-dose edoxaban in very elderly patients with atrial fibrillation

K Okumura, M Akao, T Yoshida… - … England Journal of …, 2020 - Mass Medical Soc
Background Implementation of appropriate oral anticoagulant treatment for the prevention of
stroke in very elderly patients with atrial fibrillation is challenging because of concerns …

JCS/JHRS 2020 guideline on pharmacotherapy of cardiac arrhythmias

K Ono, Y Iwasaki, M Akao, T Ikeda, K Ishii… - Circulation …, 2022 - jstage.jst.go.jp
The Japanese Circulation Society (JCS) published the “Guidelines for Pharmacological
Treatment of Arrhythmia” in 2004, and a revised edition was published in 2009. 1 Both …

D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome

Y Nishio, T Makiyama, H Itoh, T Sakaguchi… - Journal of the American …, 2009 - jacc.org
Objectives: This study aims to address whether D85N, a KCNE1 polymorphism, is a gene
variant that causes long QT syndrome (LQTS) phenotype. Background: KCNE1 encodes the …