White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral …

Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …

Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …

There is a need for increased nosological knowledge to enable rational trials in Alzheimer's
disease (AD) and related disorders. The ongoing Gothenburg mild cognitive impairment …

Introduction We estimated the age-specific duration of the preclinical, prodromal, and
dementia stages of Alzheimer's disease (AD) and the influence of sex, setting …

Objective To determine changes in the incidence of dementia between 1988 and 2015.
Methods This analysis was performed in aggregated data from individuals> 65 years of age …

Importance One characteristic histopathological event in Alzheimer disease (AD) is cerebral
amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and …

Objective We aimed to (1) assess and compare baseline plasma and CSF neurofilament
light (NfL) for cross-sectional and longitudinal associations with neuroimaging or cognition …

Objective To investigate whether greater cardiovascular fitness in midlife is associated with
decreased dementia risk in women followed up for 44 years. Methods A population-based …

Objective To investigate whether cognitive and physical activities in midlife are associated
with reduced risk of dementia and dementia subtypes in women followed for 44 years …